Eduardo A Nillni Selected Research

Pro-Opiomelanocortin (Proopiomelanocortin)

1/2018	Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.
4/2015	Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity.
3/2015	Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced obese male rats.
7/2014	Central Sirt1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced obese male rats.
6/2013	Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing.
6/2011	Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
7/2010	SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.
5/2007	Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract.
8/2004	N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin.
4/2004	Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity.

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Eduardo A Nillni Research Topics

Disease

11	Obesity 01/2018 - 04/2004
11	Body Weight (Weight, Body) 01/2018 - 05/2003
5	AIDS-Related Complex (ARC) 03/2013 - 04/2004
3	Starvation 09/2007 - 05/2004
2	Dyskinesias (Dyskinesia) 01/2020 - 11/2010
2	Hyperglycemia 04/2015 - 09/2007
2	Weight Loss (Weight Reduction) 03/2015 - 07/2014
2	Hyperthyroidism 01/2013 - 09/2007
1	Hyperphagia (Overeating) 01/2018
1	Insulin Resistance 04/2015
1	Hyperinsulinism (Hyperinsulinemia) 04/2015
1	Type 2 Diabetes Mellitus (MODY) 04/2015
1	Parkinson Disease (Parkinson's Disease) 11/2010
1	Hypersensitivity (Allergy) 07/2010
1	Metabolic Diseases (Metabolic Disease) 12/2009
1	Inflammation (Inflammations) 09/2007
1	Hypothyroidism 01/2007

Drug/Important Bio-Agent (IBA)

11	LeptinIBA 01/2018 - 05/2003
10	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2018 - 04/2004
10	Peptides (Polypeptides)IBA 12/2016 - 04/2004
5	Melanocyte-Stimulating Hormones (MSH)IBA 04/2015 - 03/2013
5	Sirtuin 1IBA 03/2015 - 12/2009
5	Proteins (Proteins, Gene)FDA Link 06/2013 - 04/2004
4	EnzymesIBA 03/2015 - 04/2004
4	Messenger RNA (mRNA)IBA 06/2013 - 04/2004
3	Hormones (Hormone)IBA 12/2016 - 12/2010
3	MelanocortinsIBA 04/2015 - 08/2004
3	NeuropeptidesIBA 06/2013 - 04/2004
3	Thyrotropin-Releasing Hormone (Protirelin)FDA Link 03/2013 - 04/2004
2	Levodopa (L Dopa)FDA LinkGeneric 01/2020 - 11/2010
2	Forkhead Box Protein O1IBA 03/2015 - 07/2014
2	Dopamine (Intropin)FDA LinkGeneric 11/2010 - 01/2007
2	Transcription Factors (Transcription Factor)IBA 09/2007 - 04/2004
2	alpha-MSHIBA 05/2007 - 04/2004
2	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 01/2007 - 04/2004
1	Cysteine (L-Cysteine)FDA Link 01/2018
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2018
1	GlucocorticoidsIBA 03/2016
1	Insulin ReceptorIBA 04/2015
1	Insulin (Novolin)FDA Link 04/2015
1	Leptin ReceptorsIBA 04/2015
1	Adrenocorticotropic Hormone (ACTH)FDA Link 06/2013
1	Appetite Depressants (Anorectics)IBA 03/2013
1	Neurotransmitter Agents (Neurotransmitter)IBA 11/2010
1	NAD (NADH)IBA 07/2010
1	Small Interfering RNA (siRNA)IBA 12/2009
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2007
1	ProlactinIBA 01/2007
1	pro-thyrotropin releasing hormoneIBA 01/2007
1	Thyroid HormonesIBA 05/2004
1	Basic Helix-Loop-Helix Transcription FactorsIBA 04/2004

Therapy/Procedure

5	Therapeutics 01/2020 - 12/2009